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Test Overview:
Please note this test for a risk marker that has been identified in the Norwich Terrier. Although the gene (and symptoms) can be seen in other breeds there is currently no correlation of this risk allele to Brachycephalic Obstructive Airway Syndrome.
Category:
Respiratory - Associated with the lungs and respiratory system
Gene:
ADAMTS3
Variant Detected:
c.2786G>A
Severity:
Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
Mode of Inheritance:
Autosomal Recessive
Research Citation(s):
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008102 https://pubmed.ncbi.nlm.nih.gov/31095560/ https://www.researchgate.net/publication/333151249_An_ADAMTS3_missense_variant_is_associated_with_Norwich_Terrier_upper_airway_syndrome
Associated Breed(s):
Boston Terrier, Boxer , British Bulldog, Bullmastiff, Cairn Terrier, Cavalier King Charles Spaniel, French Bulldog, Griffon Bruxellois - Standard, Lhasa Apso, Maltese Shih tzu, Mastiff , Pekingese, Pug, Pugalier, Shar Pei, Shih tzu,