Factor VII Deficiency

Test Overview:

Factor VII deficiency is a blood clotting disorder that causes excessive or prolonged bleeding after an injury or surgery. With factor VII deficiency, your body either doesn’t produce enough factor VII, or something is interfering with your factor VII, often another medical condition. Factor VII is a protein produced in the liver that plays an important role in helping your blood to clot. It’s one of about 20 clotting factors involved in the complex process of blood clotting. To understand factor VII deficiency, it helps to understand the role factor VII plays in normal blood clotting.


Haemolymphatic - Associated with the blood and lymph


Coagulation factor VII (F7) Chromosome 22

Variant Detected:

Base Substitution c.407G>A p.Gly136Glu


Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Callan MB, et al. A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. (2006) J Thromb Haemost. 4: 2616–22.

Associated Breed(s):

Beagle, Giant Schnauzer, Japanese Spitz, Miniature Schnauzer, Mixed Breed, Papillon, Scottish Deerhound,