Gall Bladder Mucocele Formation (Shetland Sheepdog Type)

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Test Overview:

ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi.Hepatobiliary disease in dogs has been recognized with increased frequency during the past several years. In particular, gallbladder mucoceles (mucinous hyperplasia or mucinous cholecystitis) have been documented to be an increasingly important cause of hepatobiliary disease in dogs

Category:

Digestive system / Gastrointestinal - Associated with the organs and structures of the digestive system

Gene:

ABCB4

Variant Detected:

Insertion of G

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Comp Hepatol. 2010; 9: 6.
Vet Radiol Ultrasound. 2000;41:261–271. doi: 10.1111/j.1740-8261.2000.tb01489.x

Associated Breed(s):

Mixed Breed, Shetland Sheepdog,