Hereditary Nephropathy


Urinary system / Urologic - Associated with the kidneys, bladder, ureters and urethra


Collagen type IV alpha 4 chain (COL4A4) on chromosome 25

Variant Detected:

Base Substitution c.2806C>T p.Gln905STOP


It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Nowend, KL. et al. Characterization of the genetic basis for autosomal recessive hereditary nephropathy in the English Springer Spaniel. (2012) J Vet Int Med 26;294-301.

Associated Breed(s):

English Springer Spaniel, Mixed Breed,