May-Hegglin Anomaly (Pug Type)

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Test Overview:

an inherited blood cell disorder. Symptoms include reduced numbers of platelets (normal sized), together with the presence of larger and abnormal platelets.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

Myosin heavy chain 9 (MYH9) on Chromosome 10

Variant Detected:

Base Substitution c.5600G>A p.Glu1842Lys

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Flatland B, et al. May-Hegglin anomaly in a dog. (2009) Vet Clin Path 40(2); 207-214.

Associated Breed(s):

Mixed Breed, Pug,