Necrotising Meningoencephalitis (NME)

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Test Overview:

Also known as Pug dog encephalitis, PDE this is an inflammatory disease associated with the central nervous system. This disease is progressive and can be fatal. Symptoms associated include seizures, ataxia, abnormal gait and in some cases blindness and behavourial issues.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

HLA-DRB1

Variant Detected:

linked marker test- - DLA class II genes

Severity:

Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.

Mode of Inheritance:

Autosomal Recessive with Incomplete Penetrance

Research Citation(s):

J Vet Diagn Invest. 2011 Jan;23(1):68-76
https://www.ncbi.nlm.nih.gov/pubmed/21217030

Associated Breed(s):

Peruvian Hairless Dog, Pug, Pugalier,