BREEDERS DIRECT Order Swabs

dog

cat

products

O-Store

Trapped Neutrophil Syndrome Overview

Trapped Neutrophil Syndrome
US$ 75.00 RRP
US$ 67.50 REGISTERED USER PRICE
ADD TO CART

Category: Immunological (Associated with the Immune System)

Gene: VPS13B on Chromosome 13

Variant Detected: Deletion of GTTT

Severity: Scale 4 has a high degree of severity. It generally causes a decreased quality of life and may also decrease the life expectancy.

Mode of Inheritance: Autosomal Recessive

Test Overview: Trapped Neutrophil Syndrome (TNS) is an inherited disease affecting Border Collies. This disease affects the immune system and its ability to fight infection. Affected dogs most commonly present between the ages of 6-12 weeks with signs of immune dysfunction. Symptoms of TNS are dependent on the specific infection that the dog is fighting and may include failure to thrive, poor growth, weight loss, lethargy, diarrhea and vomiting. Occasionally affected dogs can be mildly affected and not show signs of disease until 1 to 2 years of age, but typically affected dogs die from an infection by four months of age.

Research Citation(s): BMC Genomics. 2011 May 23; 12:258

Associated Breed(s): Border Collie,  Koolie ,