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The insulin-like growth factor-1 gene (IGF1), and additional studies of Miniature Poodles and Dachshunds implicated the IGF1 receptor (IGF1R) as well, both of which are important regulators of body size. The IGF1 pathway has also been established as important in normal stature in humans, and mutations in IGF1 have been shown to reduce body size in mice.
Trait (Associated with Phenotype)
chrX.g.102369488-102369489insAAC, p.Asp376_Glu377insAsn, Chromosome X
It is a trait and so is tested based on preference, not usually for health concerns.
Mode of Inheritance:
Plassais, 2017, PLoS Genet 13(3): e1006661
Associated Breed(s):American Bulldog , American Bully , American Staffordshire Terrier, Australian Stumpy Tail Cattle Dog, Border Collie, British Bulldog, Cavoodle, Finnish Lapphund, French Bulldog, Groodle, Peruvian Hairless Dog, Southern Cross Bulldog, Staffordshire Bull Terrier , White Swiss Shepherd,