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Tyrosinase-related protein 1 (TYRP1) is a protein within the melanocyte that alters the color of the skin and hair of animals. This gene is refered to as the B locus and is responsible for brown versus black coat color with brown coat colour inherited recessive to black.. The three alleles of the Brown (B) locus are designated bs, bd and bc, a combination of any two of which will cause brown coat colour.
Trait (Associated with Phenotype)
Base Substitution (Point Mutation)
It is a trait and so is tested based on preference, not usually for health concerns.
Mode of Inheritance:
Schmutz, S.M., Berryere, T.G., and Goldfinch, A.D. (2002). TYRP1 and MC1R genotypes and their effects on coat color in dogs. Mamm. Genome 13, 380–387.
Associated Breed(s):Boston Bulldog,