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Hair shape, or curl, is an essential characteristic of a dog's coat and one of the most important traits in breed standards. Between the two extreme types of hair, straight and tightly curled, there is an array of intermediate types: loose curls, spiral shaped curls, waves, etc. Hair curls are most prominent on a long hair background, but their specific characteristics depend also on hair thickness, density, and the coat growth pattern. The Cu Locus (Curly hair) impacts hair curl as a result of a DNA variant in the KRT71 gene which produces a form of keratin, a major structural component of hair. The CuC variant of KRT71 prevents keratin from binding together in a regular pattern which alters the structure of the hair and results in a curly coat.
Trait (Associated with Phenotype)
c.1266_1273delCCTGAAGCinsACA p. Ser422ArgfsTer
It is a trait and so is tested based on preference, not usually for health concerns.
Mode of Inheritance:
A second KRT71 allele in curly coated dogs A. Bauer S. Hadji Rasouliha M. T. Brunner V. Jagannathan I. Bucher J. Bannoehr K. Varjonen R. Bond K. Bergvall M. M. Welle P. Roosje T. Leeb 1. Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, VonHoldt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, Andre C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed by variants in three genes. Science. 2009 Oct; 326(5949);150-153.
Associated Breed(s):Australian Cobberdog, Australian Labradoodle , Belgian Groenendael Shepherd, Belgian Lakenois Shepherd, Belgian Malinois Shepherd, Belgian Tervueren Shepherd , Bichon Frise, Border Collie, Bordoodle, Boykin Spaniel, Chesapeake Bay Retriever , Chihuahua, Curly Coated Retriever, Groodle, Havanese, Irish Terrier, Kerry Blue Terrier, Labradoodle , Labradoodle Retrodoodle , Lagotto Romagnolo, Maltese, Portuguese Water Dog, Soft Coated Wheaten Terrier, Standard Poodle,