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Polydactyl/Dewclaws
Test Overview:
Also known as canine preaxial polydactyl (PPD) is associated with a gene inherited in a autosomal dominant mode which is involved in the expression of limb development. Dogs with one or two copies of the variant are likely to express the phenotype associated with polydactyl or rear dewclaws.
Category:
Trait (Associated with Phenotype)
Gene:
LMBR1
Variant Detected:
chr16:19380592 (canFam3): G/A
Severity:
It is a trait and so is tested based on preference, not usually for health concerns.
Mode of Inheritance:
Autosomal Dominant
Research Citation(s):
Park K, Kang J, Subedi KP, Ha JH, Park C. Canine polydactyl mutations with heterogeneous origin in the conserved intronic sequence of LMBR1. Genetics. 2008 Aug;179(4):2163-72. [PubMed: 18689889]
Associated Breed(s):
Beagle, Beaglier, Belgian Malinois Shepherd, Cockapoo, Cocker Spaniel, Rottweiler , Shetland Sheepdog, Shih tzu, Standard Poodle, Standard Schnauzer, Yorkshire Terrier,