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Autoimmune Lymphoproliferative Syndrome
Test Overview:
This disease is characterised by a build up of immune cells on the spleen and lymph nodes. Symptoms tend to be seen at around 6 to 8 weeks and progression tends to be quite rapid after that. Affected kittens show abdominal distension, tend to be lethargic and show weight loss due to anaemia.
Category:
Immunologic - Associated with the organs and cells of the immune system
Gene:
FASL
Variant Detected:
c.413-414InsA
Severity:
Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.
Mode of Inheritance:
Autosomal Recessive
Research Citation(s):
1Aberdein D, Munday JS, Gandolfi B, Dittmer KE, Malik R, Garrick DJ, Lyons LA & 99 Lives Consortium (2017). A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats. Mammalian Genome 28, 47- 55. Aberdein D, Munday JS, Fairly RA, Vernau W & Thompson KG (2015). A novel and likely inherited lymphoproliferative disease in British Shorthair kittens. Veterinary Pathology 52, 1176-1182.
Associated Breed(s):
British Longhair, British Shorthair, British Shorthair/Longhair,