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Thrombasthenic Thrombopathia (Otterhound Type)
Test Overview:
Also referred to as Glanzmanns Thombasthenia Type 1. Affected dogs have abnormal platelet activity. Platelets are blood cells that are necessary for the normal clotting of blood.
Category:
Haemolymphatic - Associated with the blood and lymph
Gene:
Integrin subunit alpha 2b (ITGA2B) on Chromosome 9
Variant Detected:
Base Substitution c.1193G>C p.Asp398His
Severity:
Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.
Mode of Inheritance:
Autosomal Recessive
Research Citation(s):
Boudreaux, MK. et al. Molecular and genetic basis for thrombasthenic thrombopathia in otterhounds. (2001) Am J Vet Res 62(11);1798-1804.
Associated Breed(s):
Mixed Breed, Otterhound,
