home

Order Tests for Dogs

DNA Tests

Hereditary Nephropathy (English Springer Spaniel)

Description

This is an inherited disorder of the kidneys affecting dogs. Normally protein is not present in the urine, but in affected dogs there is a defect that allows protein from the blood to be filtered by the kidneys and lost in the urine. Abnormal amounts of protein can be detected in the urine usually between 4-6 months of age. Symptoms of chronic kidney disease begin a few months after excessive protein is noted in the urine. Symptoms of chronic kidney disease include excessive thirst and urination, vomiting, inappetence, weight loss, weakness and fatigue. If drinking excessively, some dogs may also inappropriately urinate in the house. Affected dogs typically die of chronic kidney failure by one to two years of age.

Recommended Breeding

Diseases

Hereditary Nephropathy (English Springer Spaniel)

$ 50.00

Associated Breed(s):

Click here to view Associated Breeds

Labels:

Category:

Urinary system / Urologic - Associated with the kidneys, bladder, ureters and urethra

Severity:

Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.

Gene:

Collagen type IV alpha 4 chain (COL4A4) on chromosome 25

Variant Detected:

Base Substitution c.2806C>T p.Gln905STOP

Mode of Inheritance:

Autosomal Recessive

OMIA Reference:

Click to View Full OMIA Reference