home

Order Tests for Dogs

DNA Tests

Malignant Hyperthermia

Description

Maligant hyperthermia (MH) is an inherited disorder of skeletal muscle characterized by hypercarbia, rhabdomyolysis, generalized skeletal muscle contracture, cardiac dysrhythmia, and renal failure, that develops on exposure to succinylcholine or volatile anesthetic agents. Specific interventions, including use of the calcium release channel antagonist dantrolene, are efficacious in reversing signs of the canine syndrome.

Recommended Breeding

Diseases

Malignant Hyperthermia

$ 50.00

Associated Breed(s):

Click here to view Associated Breeds

Labels:

Category:

Metabolic - Associated with the enzymes and metabolic processes of cells

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Gene:

Ryanodine receptor 1 (RYR1) on Chromosome 1

Variant Detected:

Base Substitution c.1640T>C p.Val547Ala

Mode of Inheritance:

Autosomal Recessive

OMIA Reference:

Click to View Full OMIA Reference