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May-Hegglin Anomaly (Pug Type)

Description

May-Hegglin Anomaly is an inherited blood cell disorder. The condition is diagnosed with a microscopic examination of a blood smear and is characterised by the three key features of the presence of large platelets (macrothrombocytes), abnormal neutrophils containing structures called Inclusion Bodies, and reduced numbers of normal sized Platelets in the blood (thrombocytopenia. Symptoms can include reduced numbers of platelets (normal sized), together with the presence of larger and abnormal platelets.

Recommended Breeding

Diseases

May-Hegglin Anomaly (Pug Type)

$ 50.00

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Associated Breed(s):

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Labels:

Category:

Haemolymphatic - Associated with the blood and lymph

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Gene:

Myosin heavy chain 9 (MYH9) on Chromosome 10

Variant Detected:

Base Substitution c.5600G>A p.Glu1842Lys chr10:28120346 (canFam3): G>A

Mode of Inheritance:

Autosomal Dominant

OMIA Reference:

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