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Neuroaxonal Dystrophy (Papillon Type)

Description

Neuroaxonal dystrophy is an inherited neurological disease. Affected dogs typically present between 1-4 months of age with an abnormal gait, hindlimb weakness, and incoordination. The disease rapidly progresses to complete paralysis, blindness, and inability to eat. Affected dogs may also exhibit tremors, loss of hearing, and extension of limbs. Dogs are typically euthanized within a few months of showing clinical signs due to the severity of the disease.

Recommended Breeding

Diseases

Neuroaxonal Dystrophy (Papillon Type)

$ 50.00

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Associated Breed(s):

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Labels:

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Gene:

Phospholipase A2 group VI (PLA2G6) on Chromosome 10

Variant Detected:

Base Substitution c.1579G>A p.A526T

Mode of Inheritance:

Autosomal Recessive

OMIA Reference:

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