Neurodegenerative Vacuolar Storage Disease (Lagotto RomagnoloType)

Associated Breed(s):

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Labels:

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Gene:

Autophagy related 4D cysteine peptidase (ATG4D) on Chromosome 20

Variant Detected:

Base Substitution c.1288G>A p.Ala430Thr

Mode of Inheritance:

Autosomal Recessive