Polyneuropathy (Leonberger and Saint Bernard type) affects dogs and is an inherited neurologic disease. Dogs affected with this disease will most commonly present with signs of generalised neurologic disease including weakness, loss of muscle tone, muscle Atrophy, awkward high-stepping gait in the hind limbs, decreased reflexes, abnormal bark sounds and increased breathing sounds due to paralysis of the larynx before 3 years of age. Over time, the disease may progress to the point where affected dogs are unable to bear weight or walk. Although published reports indicate that this is an Autosomal Recessive condition in most dogs (two copies of the Mutation are required for a dog to be affected), some dogs with a single copy of the mutation (carriers) may also be at-risk of developing the disease.