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Severe Combined Immunodeficiency Disease (Terrier Type)

Description

Severe Combined Immunodeficiency Disease (Terrier Type) affects dogs and is an inherited disease.

Dogs affected with this disorder are unable to produce a protein important for proper immune function, predisposing them to severe recurrent or chronic bacterial, viral and fungal infections.

Affected dogs often present with symptoms of disease including failure to thrive, poor growth, weight loss, lethargy, diarrhoea, vomiting and lack of palpable lymph nodes around 12 to 14 weeks of age.

Affected dogs may also present with active respiratory, skin, eye or ear infections.

Puppies may die shortly after vaccination with modified live vaccines. Affected dogs die within 4 months of age.

Recommended Breeding

Diseases

Severe Combined Immunodeficiency Disease (Terrier Type)

$60.00

Associated Breed(s):

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Labels:

Category:

Immunologic - Associated with the organs and cells of the immune system

Severity:

Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.

Gene:

PRKDC

Variant Detected:

chr29:49588: G>T

Mode of Inheritance:

Autosomal Recessive with Incomplete Penetrance

OMIA Reference:

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